GARDobes: primordial cell nano-precursors with organic catalysis, compositional genome, and capacity to evolve

Daniel Segre; Dafna Ben-Eli; Yitzhak Pilpel; Ora Kedem; Doron Lancet

doi:10.1117/12.375084

30 December 1999 GARDobes: primordial cell nano-precursors with organic catalysis, compositional genome, and capacity to evolve

Daniel Segre, Dafna Ben-Eli, Yitzhak Pilpel, Ora Kedem, Doron Lancet

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Proceedings Volume 3755, Instruments, Methods, and Missions for Astrobiology II; (1999) https://doi.org/10.1117/12.375084
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1999, Denver, CO, United States

Abstract

The Graded Autocatalysis Replication Domain (GARD) model described here depicts an early primordial scenario, prior to the emergence of biopolymers, such as RNA or proteins. The model describes, with the help of statistical chemistry computer simulations, a collection of organic molecular species capable of rudimentary selection and evolution. The GARD model provides a rigorous kinetic analysis of simple sets of chemicals that manifest mutual catalysis. It is shown that catalytic closure can sustain self replication up to a critical dilution rate, related to the extent of mutual catalysis. The capacity for self replication in a mutually catalytic set is shown to be a graded property, quantitated by a critical parameter (lambda) _ci. GARD could be a simple model for a primordial scenario, in which replication and catalysis are performed by the same set of molecules.

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Daniel Segre, Dafna Ben-Eli, Yitzhak Pilpel, Ora Kedem, and Doron Lancet "GARDobes: primordial cell nano-precursors with organic catalysis, compositional genome, and capacity to evolve", Proc. SPIE 3755, Instruments, Methods, and Missions for Astrobiology II, (30 December 1999); https://doi.org/10.1117/12.375084

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