1 October 1999 Medical applications of neutron inelastic scattering
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Abstract
A sealed, D-T, pulsed neutron generator is used for the in vivo measurement of body carbon and oxygen by neutron inelastic scattering. The generator is operated at 10 KHz, at a neutron output of about 2 X 107 n/s/4(pi) . Gamma ray spectra are collected with two B4Ge3O12 crystal detectors. The measurements are used to measure fat and lean content and distribution in the body, with minimal radiation exposure (0.08 mSv). When combined with other measurements (such as total body potassium), this whole body scanning device provides us with the `quality of lean mass', a measurable outcome of treatments designed to improve nutritional status and function. The method is used in studies of human nutrition and for assessing the efficacy of new anti-obesity and anti-cachexia pharmaceuticals.
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Joseph J. Kehayias, Anathea Banuk-Waitekus, Silvia Valtuena, Charles A. Sheahan, "Medical applications of neutron inelastic scattering", Proc. SPIE 3769, Penetrating Radiation Systems and Applications, (1 October 1999); doi: 10.1117/12.363685; https://doi.org/10.1117/12.363685
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