Applications of phase-contrast x-ray imaging to medicine using an x-ray interferometer

Atsushi Momose; Akio Yoneyama; Tohoru Takeda; Yuji Itai; Jinhong Tu; Keiichi Hirano

doi:10.1117/12.368186

6 October 1999 Applications of phase-contrast x-ray imaging to medicine using an x-ray interferometer

Atsushi Momose, Akio Yoneyama, Tohoru Takeda, Yuji Itai, Jinhong Tu, Keiichi Hirano

Proceedings Volume 3770, Medical Applications of Penetrating Radiation; (1999) https://doi.org/10.1117/12.368186
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1999, Denver, CO, United States

Abstract

We are investigating possible medical applications of phase- contrast X-ray imaging using an X-ray interferometer. This paper introduces the strategy of the research project and the present status. The main subject is to broaden the observation area to enable in vivo observation. For this purpose, large X-ray interferometers were developed, and 2.5 cm X 1.5 cm interference patterns were generated using synchrotron X-rays. An improvement of the spatial resolution is also included in the project, and an X-ray interferometer designed for high-resolution phase-contrast X-ray imaging was fabricated and tested. In parallel with the instrumental developments, various soft tissues are observed by phase- contrast X-ray CT to find correspondence between the generated contrast and our histological knowledge. The observation done so far suggests that cancerous tissues are differentiated from normal tissues and that blood can produce phase contrast. Furthermore, this project includes exploring materials that modulate phase contrast for selective imaging.

Citation Download Citation

Atsushi Momose, Akio Yoneyama, Tohoru Takeda, Yuji Itai, Jinhong Tu, and Keiichi Hirano "Applications of phase-contrast x-ray imaging to medicine using an x-ray interferometer", Proc. SPIE 3770, Medical Applications of Penetrating Radiation, (6 October 1999); https://doi.org/10.1117/12.368186

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