6 October 1999 Microbeam radiation therapy
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Abstract
The central nervous system of vertebrates, even when immature, displays extraordinary resistance to damage by microscopically narrow, multiple, parallel, planar beams of x rays. Imminently lethal gliosarcomas in the brains of mature rats can be inhibited and ablated by such microbeams with little or no harm to mature brain tissues and neurological function. Potentially palliative, conventional wide-beam radiotherapy of malignant brain tumors in human infants under three years of age is so fraught with the danger of disrupting the functional maturation of immature brain tissues around the targeted tumor that it is implemented infrequently. Other kinds of therapy for such tumors are often inadequate. We suggest that microbeam radiation therapy (MRT) might help to alleviate the situation. Wiggler-generated synchrotron x-rays were first used for experimental microplanar beam (microbeam) radiation therapy (MRT) at Brookhaven National Laboratory's National Synchrotron Light Source in the early 1990s. We now describe the progress achieved in MRT research to date using immature and adult rats irradiated at the European Synchrotron Radiation Facility in Grenoble, France, and investigated thereafter at the Institute of Pathology of the University of Bern.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Jean A. Laissue, Jean A. Laissue, Nadia Lyubimova, Nadia Lyubimova, Hans-Peter Wagner, Hans-Peter Wagner, David W. Archer, David W. Archer, Daniel N. Slatkin, Daniel N. Slatkin, Marco Di Michiel, Marco Di Michiel, Christian Nemoz, Christian Nemoz, Michel Renier, Michel Renier, Elke Brauer, Elke Brauer, Per O. Spanne, Per O. Spanne, Jan-Olef Gebbers, Jan-Olef Gebbers, Keith Dixon, Keith Dixon, Hans Blattmann, Hans Blattmann, "Microbeam radiation therapy", Proc. SPIE 3770, Medical Applications of Penetrating Radiation, (6 October 1999); doi: 10.1117/12.368185; https://doi.org/10.1117/12.368185
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