Fluorescence array scanner

Jean I. Montagu; Peter Honkanen

doi:10.1117/12.368219

5 October 1999 Fluorescence array scanner

Jean I. Montagu, Peter Honkanen

Proceedings Volume 3779, Current Developments in Optical Design and Optical Engineering VIII; (1999) https://doi.org/10.1117/12.368219
Event: SPIE's International Symposium on Optical Science, Engineering, and Instrumentation, 1999, Denver, CO, United States

Abstract

DNA-based fluorescent microarrays are fast becoming the preferred tool for studying a variety of complex biochemical phenomena ranging from multiplex mutation detection, to gene mapping and expression monitoring, and high throughput screening for new drug candidates. Fluorescence is a low energy phenomenon. The need for rapid, high resolution, wide field imaging of fluorescent microarrays calls for a specialized microscope architecture. We now describe the design of a 'Flying Objective' epi-fluorescence microscope that is ideally suited to this application, and compare the performance of this novel instrument with two other commercial epi-fluorescence microscopes designed to read DNA microarrays.

Citation Download Citation

Jean I. Montagu and Peter Honkanen "Fluorescence array scanner", Proc. SPIE 3779, Current Developments in Optical Design and Optical Engineering VIII, (5 October 1999); https://doi.org/10.1117/12.368219

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