We counted expedient to include different methods of the soft-laser use in the preoperative medicinal program and in the postoperative period. During the preoperative preparation the basic group patients together with standard treatment received the combined soft-laser therapy, which included intravenous laser blood irradiation (ILBI) by He-Ve laser and external transcutaneous irradiation of the abscess projection by semi-conductorial arrenite-gallium laser. During postoperative treatment with ILBI remarkable changes were observed in the functional activity of the T- and B- cell. The soft-laser use allowed to achieve improvement of quality and shortening of terms of the preoperative preparation of 1,4 times, to level the immunosuppressive influence of surgery to reduce amount of the postoperative complications in 1,8 times and duration of the postoperative period in 1,5 times.

The efficiency of a diode laser with a wavelength 0,81 microns in treatment of an open-angle glaucoma is investigated. The diode LTP is a pathogenesis oriented method of treatment of an open angle glaucoma: it gives in improvement of outflow of an intraocular fluid, stabilization and improvement of visual functions for patients with initial and developed stages of disease at term of observation up to 12 months.

Extremely slow introduction of low-level laser therapy into the practice of ophthalmologists is restricted by the lack of good methodological recommendation and modern equipment adopted to the needs of ophthalmology. The most perspective is considered to be further improvement of the methods and the elaboration of the medical equipment, working in several wave bands, combined with magnetotherapy and working with the use of various modes of the modulation of the intensity of the luminous flux. It may be asserted that unlike the mode of continuous radiation, in some cases, the effectiveness of the treatment increases when the modulated light with the frequency of one to a few tens HZ is used. Moreover, the methods are being elaborated, when the modulation frequency of laser light and the biorhythms of man physiologic parameters are synchronized. Very perspective seems the computerization of the treatment process with the simultaneous electrophysiological control of the condition of visual functions.

The new method of treatment for destructive lung tuberculosis described in this work actually represents a modification a puncture or drainage technique used to have a local action on the tubercular cavern supplemented by an additional treatment with UV laser radiation. Medical laser 'Al mitsin-2' has next parameters: average radiation pover- 20 mW, pulse duration-6 ns, design- monoblok, beam extraction-fiber waveguide, readiness time-3 min, exposure time-0,1-99, 9 min, lifetime-5000 h, dimensions-240 X 330 X 440 mm, mass-27 kg. Among destructive tuberculosis patients 14,0 percent were discharged from the hospital with complete clinical effect without surgery, 42,1 percent patients underwent surgery, 21,1 percent of the patients were discharged with obvious improvement without surgery because they refused surgery and 22,8 percent of patients were contradicted due to a progress of destructive tuberculosis of lungs and severe accompanying diseases. Evaluating the overall results of the treatment using laser endocavital irradiation method for patients with destructive lung tuberculosis we consider this approach effective both for the improvement of the basic course of chemotherapy and stabilization of tuberculosis progressing in per-surgery period of treatment.

The tuberculosis of an urine bladder in men develops is authentic less often, and recovery is authentic more often, than in the women. In 39,1 percent of the women with nephrotuberculosis and urocystis and urocystis tuberculosis a specific cystitides is finished in development of post- tuberculous cystalgia. One of starting mechanism of dysuria after the transferred urocystis tuberculosis in the women in menopause is hormonal insufficiency. The method of laser heat puncturing, developed by us, for the treatment this complication is highly effective, does not require additional introduction of medicines, can be executed as in hospitals, and in our-patient.

The response of a human organism on weak stimulation of the acupuncture points and zones has been studied. The structure of an acupuncture point and its role as an information window have been discussed. Some aspects of links between the state of internal organs and skin characteristics have ben revealed. The kinetic electropuncture diagnostics has presented as a method to analyze the organism response measuring the temporal kinetics of potentials in stimulated acupuncture points. Biophysical and biochemical processes which determine the kinetics of the measured potentials have been considered. The principles of registered data processing and the construction of decision rules have been discussed. The hardware-software complex CASKED built on the bias of the kinetic electropuncture diagnostics and the functional scheme of CASKED hardware have been presented. The diagnostic routines consisting of two stages has been described. It has been shown that there is the correspondence between the physiological state of AP and the clinical diagnosis.

The aim of these experiments was a direct measurement of changes in absorption of cellular monolayers under diode laser irradiation. First, a sensitive method for multichannel registration of absorption of a cell monolayer in range 500-860 nm was developed. Second, absorption spectra of intact HeLa cells and those after irradiation the monolayer with light at 670 and 820 nm were recorded. Third, the comparison of the absorption spectra and action was performed.

As an object of study extracted human teeth were used. The whole was explored 30 teeth; measurements were conducted in intact regions of tooth: enamel, dentine, cement, root canal and in pathologically changed areas: caries of teeth and a solid teeth plaque. From present fluorescent spectrums of intact: enamel, dentine, cement; and of pathological: caries and teeth stone is seen that curves are likely shaped for each of the groups, but their amplitudes are not the same. Fluorescence maximum of all tooth areas falls on 700 nm, herewith possible to say that, spectrum shapes are specific for each tooth area, that can be used in diagnostic purposes, for example when processing a carious cavity. As to florescence intensity that teeth stone possesses the maximum of fluorescence, then an area submitted to caries, intact areas possess a weak fluorescence.

Most further development of a method of a fluorescent diagnostics must be directed on the creation of database, revealed in the informative criterion of a process and their factorial analyses with a computer reflection of the results and their visualization in real time. All this will make it possible to use fluorescent technique.

Presented a method and an equipment for dermabrasion where radiation of CO2 laser is used. An effort to make amplitude- frequency features of scanning device and clinical strategy more objective were taken. Presented preliminary results of clinical approbations of the equipment and the method.

An analyzer of ¹³CO₂/¹²CO₂ ratio in exhaled air based on lead-salt tunable diode lasers is presented. High accuracy of the carbon isotope ratio detection in exhaled carbon dioxide was achieved with help of very simple optical schematics. It was based on the use of MBE laser diodes operating in pulse mode and on recording the resonance CO₂ absorption at 4.2 micrometers . Special fast acquisition electronics and software were applied for spectral data collection and processing. Developed laser system was tested in a clinical train aimed to assessment eradication efficiency in therapy of gastritis associated with Helicobacter pylori infection. Data on the ¹³C-urea breath test used for P.pylori detection and obtained with tunable diode lasers in the course of the trail was compared with the results of Mass-Spectroscopy analysis and histology observations. The analyzer can be used also for ¹³CO₂/¹²CO₂ ratio detection in exhalation to perform gastroenterology breath test based on using other compounds labeled with stable isotopes.

Middle IR tunable diode lasers were applied to studies of pulmonary excretion of endogenous carbon monoxide (CO). Variations of the CO content level in exhaled air of healthy nonsmokers were investigated for different environmental conditions with the applied laser technique. Correlation of the obtained data with atmospheric CO contamination and elevated oxygen content were studied as well as diurnal variations of the endogenous CO in exhalation was observed. Criteria for correct conditions of the endogenous CO detection in breath could be derive don this basis. Developed laser approach and methods were applied for the analysis of the excreted CO level in different diseases like bronchial asthma, cystic fibrosis, idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease, anemia and hepatitis. Laser based close-to-real-time monitoring of the endogenous CO elimination with breath in the course of different dynamic tests was demonstrated to be informative in studies of blood oxygen transport and pH variations in tissues for different challenges tests in human physiology.

Mathematical calculation model of spreading a laser radiating is offered in the article in non-homogeneous, scattering and fluorescent biological tissues and mediums, based on solving a transport equation by the method the moments. In this article present results of modeling the conduct of fluorescent radiating for different optical characteristics of medium t in purposes of development theoretical basis of laser fluorescent diagnostics in medicine.

An analyzer aimed for single-breath detection of exhaled endogenous NO is described. It is based on lead-salt MBE tunable diode lasers (TDL) operating at 5.4 micrometers spectral region. Specially designed high sensitive and fast acquisition system used in combination with the Herriott multipass gas cell allows 1 ppb concentration sensitivity to exhaled NO with about 0.5 s temporal resolution. Careful selection of the used analytical spectral region ensures high NO detection selectivity in the conduction if elevated water vapor and carbon dioxide content in exhaled air. Due to the TDL high spectral resolution the analyzer is also insensitive to the other numerous endogenous substances that could be present in exhaled air. The TDL NO analyzer was tested in measuring endogenous NO content in exhalation of patients suffering from different pulmonary diseases as well as of healthy control subjects. Some single-breath NO trace specific in asthma and COPD was observed allowing differentiation of these diseases with the exhalation NO test.

During the last years the interest towards the researchers of the effect of laser radiation (LR) on the biological tissues has increased. The phenomenons of absorption, reflection and scattering of LR in the oral tissues are essential for the proper treatment. The penetration and absorption in those tissues and stomatological materials for different wavelengths of LR have been investigated in our previous works. The main purpose of this study is to investigate the scattering of He Ne laser radiation in oral tissues.

Conducted studies on studying the possibility of registration of monoculture of an anaerobic microorganisms and their mixtures by the method of laser fluorescent diagnostics.

The description of ophthalmological excimer laser system 'PROFILE-500' for photorefractive and physiotherapeutic keratectomy is presented. Excimer Laser Systems 'PROFILE- 500' are optical system that use ArF excimer lasers to perform photorefractive keratectomy or LASIK; surgical procedures used to correct myopia, hyperopia and astigmatism.

In experiments were worked out an din clinical practice were approved two original techniques of photocoagulation- photoablation destruction of rather volumetric intraocular tumors by thickness greater than 3 mm with the help of deeply penetrating IR laser radiations of A-range. In variant of transpupillary effect preference returned to quasicontinuous radiations ophthalmonocoagulator 'Landoga- Neodymium'. At pulse duration measurable in hundreds of microseconds with frequency of following up to 50 Hz and energy in impulse about 100 millijoules it was possible to destroy tumors in 85 cases among 122. Total absorbed energy in the target was varied from 500 until 1500 Joules. Periods of observation last 4-12 years. Diode laser of the 'Milon' corporation with a glass-fiber tip was applied in a course of vitreoectomy in variant of contact compressive effects on juxtapapillary located tumors. Applies constant radiation power 1.6 W. Tumors were liquidated at total absorbed energy also up to 500 pulses in 11 cases among 12. Periods of observation laser 2-4 years. Both variants of laser treatment deserve more broad application in clinical practice.

A compact, solid-state, high-efficiency, and safe UV laser medical system with optical fiber output was created for treatment of destructive forms of pulmonary tuberculosis. A frequency-quadruped quasi-CW Nd:YVO₄ laser system pumped by laser-diode array is investigated with various resonator configurations. A longitudinal end-pumping scheme was used in a compact acousto-optical Q-switched laser for producing stable pulses of UV radiation at the repetition frequency 10-20 kHz and the duration 7-10 ns with the fiber-guide output power exceeding 10 mW.

This paper presents a new technology, which consists in utilizing laser drug delivery methods for the purposes of photodrug therapy. According to this technology, photosensitizer is applied onto the treated surface and then the solution is either impregnated or injected into the medium, with it being suggested to employ laser drug delivery techniques for the impregnation and injection of the photosensitizer. After introducing the photosensitizer, the area is illuminated by a matrix of light-emission diodes.

A concept of the homeostasis consisting of two system: autotherapeutic and autodiagnostic has been presented. The structure and functions of the autodiagnostic system have been described. Correspondences between the concepts of Chinese medicine and the neurocomputing paradigms have been discussed.

A hypothesis is formulated, according to which there are two interconnected systems in an organism: autodiagnostic (ADS) and autotherapeutic (ATS). ATS functioning is based on the result of ADS operation. The structure and functions of ADS are considered form positions of the recognition theory, neurocomputing and neurophysiology. Based on the modern investigations and available biochemical and morphological data the mechanism of the Rexed plates operation as a whole and each plate separately is considered.

A detailed study of the lasing of a promising surgical 1.44 micrometers Nd:YAG laser was done. This wavelength provides practically the same effects in laser emission - tissue as compared to 2 micrometers holmium lasers, but demonstrates the better operation in a high average power, high pulse repetition rate mode. The physical properties of the laser are discussed to solve the problem of the increasing the efficiency of operation.