9 December 1999 Tapered tubular optical waveguide probe for magnetic focusing immunosensors
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Abstract
A novel fluorescence immunosensor using a tapered tubular optical waveguide probe for analyte detection has been developed based on magnetic focusing of paramagnetic microspheres. The new design features a tubular optical waveguide tapered at both ends with a tapered magnet embedded inside of the waveguide. The excitation light is injected from the middle part of the tubular waveguide and is guided to the front end where it illuminates paramagnetic particles attracted by the magnet. The associated fluorescent signal is collected by the optical probe and is guided to the distal end, where it is connected to the optical detection system. The waveguide thus serves multiple purposes: the front end of the waveguide serves as the optical probe while the rear end serves as the connector to the signal transmission fiber; the waveguide body serves as a holder for the magnet, a directional coupler for the excitation and a high split-ratio coupler for the fluorescent signal.
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He Cao, Philip E. Pivarnik, Arthur Garth Rand, Hazem Baqaen, Stephen V. Letcher, "Tapered tubular optical waveguide probe for magnetic focusing immunosensors", Proc. SPIE 3860, Fiber Optic Sensor Technology and Applications, (9 December 1999); doi: 10.1117/12.372959; https://doi.org/10.1117/12.372959
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