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17 September 1999 Ischemic stroke assessment with near-infrared spectroscopy
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Proceedings Volume 3863, 1999 International Conference on Biomedical Optics; (1999)
Event: International Symposium on Biomedical Optics, 1999, Wuhan, China
Many authors have elucidated the theory about oxygenated hemoglobin, deoxygenated hemoglobin absorption in near-infrared spectrum. And the theory has opened a window to measure the hemodynamic changes caused by stroke. However, no proper animal model still has established to confirm the theory. The aim of this study was to validate near-infrared cerebral topography (NCT) as a practical tool and to try to trace the focal hemodynamic changes of ischemic stroke. In the present study, middle cerebral artery occlusion model and the photosensitizer induced intracranial infarct model had been established. NCT and functional magnetic resonance image (fMRI) were obtained during pre- and post-operation. The geometric shape and infarct area of NCT image was compared with the fMRI images and anatomical samples of each rat. The results of two occlusion models in different intervene factors showed the NCT for infarct focus matched well with fMRI and anatomic sample of each rats. The instrument might become a practical tool for short-term prediction of stroke and predicting the rehabilitation after stroke in real time.
© (1999) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Weiguo Chen, Pengcheng Li, Shaoqun Zeng, Qingming Luo, and Bo Hu "Ischemic stroke assessment with near-infrared spectroscopy", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999);

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