Microchips for DNA sequencing

Carlos H. Mastrangelo; S. Palaniappan; Piu Francis Man; Mark A. Burns; David T. Burke

doi:10.1117/12.359324

19 August 1999 Microchips for DNA sequencing

Carlos H. Mastrangelo, S. Palaniappan, Piu Francis Man, Mark A. Burns, David T. Burke

Proceedings Volume 3877, Microfluidic Devices and Systems II; (1999) https://doi.org/10.1117/12.359324
Event: Symposium on Micromachining and Microfabrication, 1999, Santa Clara, CA, United States

Abstract

Genetic information is vital for understanding features and response of an organism. In humans, genetic errors are linked to the development of major diseases such as cancer and diabetes. In order to maximally exploit this information it is necessary to develop miniature sequencing assays that are rapid and inexpensive. In this paper we show how this could be attained with microfluidic chips that contain integrated assays. To date simple silicon/glass chips aimed for sequencing purpose have been realized; but these chips are not yet practical. Some of the solutions that are used to bring these devices closer to commercial applications are discussed.

Citation Download Citation

Carlos H. Mastrangelo, S. Palaniappan, Piu Francis Man, Mark A. Burns, and David T. Burke "Microchips for DNA sequencing", Proc. SPIE 3877, Microfluidic Devices and Systems II, (19 August 1999); https://doi.org/10.1117/12.359324

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