17 May 2000 Noninvasive in-vivo near-infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near-surface tissues
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Proceedings Volume 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X; (2000) https://doi.org/10.1117/12.386241
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Abstract
We report the use of near infrared vibrational spectroscopy to noninvasively probe the in-vivo lipid and aqueous phases of skin and near surface tissues under conditions of thermal and chemical modulation. We demonstrate thermally induced order- disorder transitions in lipids that can be directly compared to well known behavior of in-vitro samples of phospholipid bilayers and bulk fatty acids. We show reversible chemical modification of aqueous phase proteins which are also directly comparable to well known phenomena involving in-vitro proteins. The results of these studies demonstrate the capacity for noninvasively probing live human tissues on the molecular level using near infrared vibrational spectroscopy. This capacity suggests numerous potential applications ranging from assessing the efficacy of cosmetics, skin care treatments and transdermal therapeutic agents/treatments to serving as a diagnostic of various skin ailments, e.g. melanoma.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Joseph Chaiken, Joseph Chaiken, William F. Finney, William F. Finney, Karen P. Peterson, Karen P. Peterson, Charles M. Peterson, Charles M. Peterson, Paul E. Knudson, Paul E. Knudson, Ruth S. Weinstock, Ruth S. Weinstock, Paul Lein, Paul Lein, } "Noninvasive in-vivo near-infrared vibrational spectroscopic study of lipid and aqueous phases of skin and near-surface tissues", Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386241; https://doi.org/10.1117/12.386241
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