Photodynamic therapy (PDT) with endoscopic ultrasound for the treatment of esophageal cancer

Timothy A. Woodward M.D.; Herbert C. Wolfsen

doi:10.1117/12.386281

17 May 2000 Photodynamic therapy (PDT) with endoscopic ultrasound for the treatment of esophageal cancer

Timothy A. Woodward M.D., Herbert C. Wolfsen

Proceedings Volume 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X; (2000) https://doi.org/10.1117/12.386281
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

In 1995, PDT was approved for palliative use in patients with esophageal cancer. We report our experience using PDT to treat esophageal cancer patients previously treated with combination chemotherapy and radiation therapy. In our series, nine patients referred for PDT with persistent esophageal cancer after chemo-radiation therapy. We found: (1) All patients were men with a mean age of 63 years and eight out of nine had adenocarcinoma with Barrett's esophagus; (2) All patients required endoscopic dilation after PDT; (3) At a mean follow up of 4 months, two T2N0 patients had no demonstrable tumor and all three T3N0 patients had greater than 50% tumor reduction (the partially responsive T3N0 patients will be offered repeat PDT); (4) Patients with metastatic disease (T3N1 or M1) had effective dysphagia palliation. Thus, PDT is safe and effective in ablating all or most tumor in patients with persistent esophageal cancer after chemotherapy and radiation therapy.

Citation Download Citation

Timothy A. Woodward M.D. and Herbert C. Wolfsen "Photodynamic therapy (PDT) with endoscopic ultrasound for the treatment of esophageal cancer", Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); https://doi.org/10.1117/12.386281

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