17 May 2000 Uptake and distribution of fluorescently labeled cobalamin in neoplastic and healthy breast tissue
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Proceedings Volume 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X; (2000) https://doi.org/10.1117/12.386306
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Abstract
Fluorescent analogs of cobalamin (vitamin B12) have been developed as diagnostic markers of cancer cells. These compounds are recognized by transcobalamin, a cobalamin transport protein, with high affinity, as shown by surface plasmon resonance. The cellular sequestration and gross distribution of fluorescent cobalamin bioconjugates in breast tissue is being examined by epifluorescence microscopy. The distribution of each compound is being evaluated in proliferative and non-proliferative tissue, i.e. normal tissue and breast carcinoma. The results of preliminary studies suggest that fluorescent analogs of cobalamin may be a useful tool in therapeutic breast operations to define tumor margins and to distinguish neoplastic breast tissue from healthy breast tissue.
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Michelle J. Cannon, Michelle J. Cannon, James M. McGreevy, James M. McGreevy, Joseph A. Holden, Joseph A. Holden, Frederick G. West, Frederick G. West, Charles B. Grissom, Charles B. Grissom, } "Uptake and distribution of fluorescently labeled cobalamin in neoplastic and healthy breast tissue", Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); doi: 10.1117/12.386306; https://doi.org/10.1117/12.386306
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