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7 June 2000 Free-electron laser effects on fibrin tissue glue: a preliminary study
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Proceedings Volume 3908, Ophthalmic Technologies X; (2000)
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
One glaucoma challenge is the treatment of leaking trabeculectomy blebs. Simple methods such as patching, autologous blood injection, compression sutures or cyanoacrylate glue application often fail. Because the conjunctiva is thin and ischemic, it often can't be sutured together so major surgery is required to excise the thin tissue and advance healthy conjunctiva. We report the preliminary results of Tisseel and Tisseel treated with two wavelengths from Vanderbilt's free electron laser placed on leaking trabeculectomy bleb holes in Dutch belted rabbits. The holes were healed at one week in the sutured group and in the 7.7 micrometer FEL-treated Tisseel group. One hole was healed in the cyanoacrylate glue-treated group. Holes remained in the other treatment groups. Tisseel irradiated with 7.7 micrometer energy from the free electron laser may promote healing of trabeculectomy bleb holes.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Karen Margaret Joos M.D., Katie Topadze, Charles Shieh, Jin-Hui Shen, and Vivien A. Casagrande "Free-electron laser effects on fibrin tissue glue: a preliminary study", Proc. SPIE 3908, Ophthalmic Technologies X, (7 June 2000); doi: 10.1117/12.387516;

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