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29 March 2000 Clinical trials of photodynamic therapy of malignant brain tumors
Paul J. Muller M.D., Brian C. Wilson, Lothar D. Lilge, Victor X.D. Yang, Mike H. Hitchcock, Fred W. Hetzel, Qun Chen, T. Fullager, Robert Fenstermaker, Robert Selker, Judith Abrams
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Proceedings Volume 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX; (2000) https://doi.org/10.1117/12.379894
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Abstract
Photodynamic therapy (PDT) is a local treatment for malignment tumors. In a phase 2 trial in patients with supratentorial gliomas treated with 2 mg/kg Photofrin i.v. and intraoperative cavitary PDT, we were able to conclude that PDT was safe in patients with either newly diagnosed or recurrent supratentorial malignant gliomas. There appears to be prolongation of survival in selected patients when an adequate light dose is used. The surgical mortality rate was less than 3 percent.
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Paul J. Muller M.D., Brian C. Wilson, Lothar D. Lilge, Victor X.D. Yang, Mike H. Hitchcock, Fred W. Hetzel, Qun Chen, T. Fullager, Robert Fenstermaker, Robert Selker, and Judith Abrams "Clinical trials of photodynamic therapy of malignant brain tumors", Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); https://doi.org/10.1117/12.379894
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KEYWORDS
Photodynamic therapy
Tumors
Brain
Clinical trials
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