Novel drug form of chlorin e6

Andrei V. Reshetnickov; Gelii V. Ponomarev; Olga Yu. Abakumova; Tatyana A. Tsvetkova; Artashes V. Karmenyan; Aleksei G. Rebeko; Rudolf Ph. Baum

doi:10.1117/12.379889

29 March 2000 Novel drug form of chlorin e6

Andrei V. Reshetnickov, Gelii V. Ponomarev, Olga Yu. Abakumova, Tatyana A. Tsvetkova, Artashes V. Karmenyan, Aleksei G. Rebeko, Rudolf Ph. Baum

Author Affiliations +

Proceedings Volume 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX; (2000) https://doi.org/10.1117/12.379889
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Chlorine₆ has been known to be attractive as photosensitizer (PS) for PDT for long. Its usefulness as a photosensitizing part of photoimmunotoxines for targeted PDT, as a synton for further chemical modification and as a promising PS has been widely recognized. There is a patented procedure at our disposal now allowing for preparation of a stable, well soluble and filtrating form of chlorine₆- 'Photodithazine'. The elaborated production technology includes 4 steps. 'Photodithazine's 1-octanol/Phosphate buffer, pH 7.4 partition coefficient has been found to be 1.4, indicating that it must be able to localize in the plasma membrane. This may be a partial explanation of its higher photodynamic efficacy in vitro, comparing to 'Photosense' and its closeness to 'Photogem'.

Citation Download Citation

Andrei V. Reshetnickov, Gelii V. Ponomarev, Olga Yu. Abakumova, Tatyana A. Tsvetkova, Artashes V. Karmenyan, Aleksei G. Rebeko, and Rudolf Ph. Baum "Novel drug form of chlorin e6", Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); https://doi.org/10.1117/12.379889

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available