29 March 2000 Novel drug form of chlorin e6
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Proceedings Volume 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX; (2000) https://doi.org/10.1117/12.379889
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Abstract
Chlorine6 has been known to be attractive as photosensitizer (PS) for PDT for long. Its usefulness as a photosensitizing part of photoimmunotoxines for targeted PDT, as a synton for further chemical modification and as a promising PS has been widely recognized. There is a patented procedure at our disposal now allowing for preparation of a stable, well soluble and filtrating form of chlorine6- 'Photodithazine'. The elaborated production technology includes 4 steps. 'Photodithazine's 1-octanol/Phosphate buffer, pH 7.4 partition coefficient has been found to be 1.4, indicating that it must be able to localize in the plasma membrane. This may be a partial explanation of its higher photodynamic efficacy in vitro, comparing to 'Photosense' and its closeness to 'Photogem'.
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Andrei V. Reshetnickov, Gelii V. Ponomarev, Olga Yu. Abakumova, Tatyana A. Tsvetkova, Artashes V. Karmenyan, Aleksei G. Rebeko, Rudolf Ph. Baum, "Novel drug form of chlorin e6", Proc. SPIE 3909, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IX, (29 March 2000); doi: 10.1117/12.379889; https://doi.org/10.1117/12.379889
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