Optical measurement of photosensitizer concentration using a probe with a small source-detector fiber separation

Murat Canpolat; Judith R. Mourant

doi:10.1117/12.384915

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3 May 2000 Optical measurement of photosensitizer concentration using a probe with a small source-detector fiber separation

Murat Canpolat, Judith R. Mourant

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Proceedings Volume 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II; (2000) https://doi.org/10.1117/12.384915
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We present a novel minimally invasive method to measure the concentration of photodynamic therapy drugs in real time. The method is based on measurements of backscattered and fluorescence light using a steady state fluorescence spectrometer. The ratio of the fluorescence to scattered light is found to be linearly proportional to the absorption coefficient of the photosensitizer. The fiber-optic probe used for the measurements has a small source-detector separation, therefore the measurements could be performed through the working channel of an endoscope.

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Murat Canpolat and Judith R. Mourant "Optical measurement of photosensitizer concentration using a probe with a small source-detector fiber separation", Proc. SPIE 3911, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems II, (3 May 2000); https://doi.org/10.1117/12.384915

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