Optically active nanoparticles for ultrasensitive detection and spectroscopy

Dustin J. Maxwell; John T. Krug II; Shuming Nie

doi:10.1117/12.382024

11 April 2000 Optically active nanoparticles for ultrasensitive detection and spectroscopy

Dustin J. Maxwell, John T. Krug II, Shuming Nie

Proceedings Volume 3913, In-Vitro Diagnostic Instrumentation; (2000) https://doi.org/10.1117/12.382024
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Recent research in our lab has identified a new class of metal nanoparticles that are highly efficient for surface- enhanced optical spectroscopy. By coupling nanoparticles with surface-enhanced Raman scattering (SERS), surface optical processes can be enhanced by 14 to 15 orders of magnitude. This enormous enhancement allows the optical detection of single molecules at room temperature. However, in a standard silver colloid only 1 out of 100 nanoparticles is SERS-active. In this report, a new methodology based on size-selective filtration is demonstrated. This size- selective fractionation procedure yields an enriched colloid that can be used to prepare highly efficient nanoparticle thin films.

Citation Download Citation

Dustin J. Maxwell, John T. Krug II, and Shuming Nie "Optically active nanoparticles for ultrasensitive detection and spectroscopy", Proc. SPIE 3913, In-Vitro Diagnostic Instrumentation, (11 April 2000); https://doi.org/10.1117/12.382024

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