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11 April 2000 Optically active nanoparticles for ultrasensitive detection and spectroscopy
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Proceedings Volume 3913, In-Vitro Diagnostic Instrumentation; (2000)
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Recent research in our lab has identified a new class of metal nanoparticles that are highly efficient for surface- enhanced optical spectroscopy. By coupling nanoparticles with surface-enhanced Raman scattering (SERS), surface optical processes can be enhanced by 14 to 15 orders of magnitude. This enormous enhancement allows the optical detection of single molecules at room temperature. However, in a standard silver colloid only 1 out of 100 nanoparticles is SERS-active. In this report, a new methodology based on size-selective filtration is demonstrated. This size- selective fractionation procedure yields an enriched colloid that can be used to prepare highly efficient nanoparticle thin films.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dustin J. Maxwell, John T. Krug II, and Shuming Nie "Optically active nanoparticles for ultrasensitive detection and spectroscopy", Proc. SPIE 3913, In-Vitro Diagnostic Instrumentation, (11 April 2000);

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