Corneal and skin laser exposures from 1540-nm laser pulses

Thomas E. Johnson; Michael A. Mitchell; Pedro J. Rico; David J. Fletcher D.V.M.; Thomas E. Eurell; William P. Roach

doi:10.1117/12.388049

13 June 2000 Corneal and skin laser exposures from 1540-nm laser pulses

Thomas E. Johnson, Michael A. Mitchell, Pedro J. Rico, David J. Fletcher D.V.M., Thomas E. Eurell, William P. Roach

Author Affiliations +

Proceedings Volume 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical; (2000) https://doi.org/10.1117/12.388049
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Mechanisms of tissue damage are investigated for skin and cornea exposures from 1540 nm ('eye safe') laser single pulses of 0.8 milli-seconds. New skin model data point out the advantages of using the Yucatan mini-pig versus the Yorkshire pig for in-vivo skin laser exposures. Major advantages found include similarities in thickness and melanin content when compared with human skin. Histology from Yucatan mini-pig skin exposures and the calculation of an initial ED₅₀ threshold indicate that the main photon tissue interaction may not be solely due to water absorption. In-vitro corneal equivalents compared well with in-vivo rabbit cornea exposure under similar laser conditions. In-vivo and in-vitro histology show that initial energy deposition leading to damage occurs intrastromally, while epithelial cells show no direct injury due to laser light absorption.

Citation Download Citation

Thomas E. Johnson, Michael A. Mitchell, Pedro J. Rico, David J. Fletcher D.V.M., Thomas E. Eurell, and William P. Roach "Corneal and skin laser exposures from 1540-nm laser pulses", Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); https://doi.org/10.1117/12.388049

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