Formation of nitric oxide under action of UV and visible light on S-nitrosocompounds

Ivan I. Stepuro; Raisa I. Adamchuk; Slavomir S. Anufrik; Vitali I. Stepuro; Sergei A. Maskevich

doi:10.1117/12.388077

13 June 2000 Formation of nitric oxide under action of UV and visible light on S-nitrosocompounds

Ivan I. Stepuro, Raisa I. Adamchuk, Slavomir S. Anufrik, Vitali I. Stepuro, Sergei A. Maskevich

Proceedings Volume 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical; (2000) https://doi.org/10.1117/12.388077
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

It has been shown that NO is released under the exposure of the aqueous solutions of S-nitrosocompounds as well as blood plasma proteins and whole blood of healthy donors to UV and visible light. The NO release from degrading S- nitrosocompounds was monitored both spectrophotometrically (by nitrosohemoglobin formation) and using the quenching of pyrene fluorescence by nitric oxide. In addition to NO, thyil radicals which dismutate to disulfides, were formed under anaerobic conditions. In the presence of oxygen, peroxide compounds, cysteine acid derivatives and S-nitrocompounds are formed apart from disulfides, and NO is mainly converted to NO₂^-. It is suggested that NO releasing under the actin of UV and visible light from physiological depots induces vascular relaxation, which enhances the blood flow.

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Ivan I. Stepuro, Raisa I. Adamchuk, Slavomir S. Anufrik, Vitali I. Stepuro, and Sergei A. Maskevich "Formation of nitric oxide under action of UV and visible light on S-nitrosocompounds", Proc. SPIE 3914, Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical, (13 June 2000); https://doi.org/10.1117/12.388077

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