28 April 2000 Analyses of the sample volume for fiber optics and confocal detecting probe in backscattered spectral investigations of the skin
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Proceedings Volume 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV; (2000) https://doi.org/10.1117/12.384160
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Abstract
Photon migration through skin tissue leads to a poorly defined 'sampling volume' so that the optical signal represents a spatial average over cell layers 1 mm deep or more. This problem is well known in the field of Laser Doppler Flowmetry. The current work is to theoretically investigate to what extent we can localize the sampling volume of reflectance spectroscopy to the upper layers of skin. The results of Monte Carlo simulation of the degree of photon spatial localization for different kind of optical probes are given. Such localization is very important for the clinical interpretation of the results, as capillary loops are responsible for the delivery of nutrients to the epidermis, whereas deeper vessels are primarily thermo regulatory in function.
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Igor Victorovich Meglinski, Igor Victorovich Meglinski, Stephen John Matcher, Stephen John Matcher, } "Analyses of the sample volume for fiber optics and confocal detecting probe in backscattered spectral investigations of the skin", Proc. SPIE 3915, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications IV, (28 April 2000); doi: 10.1117/12.384160; https://doi.org/10.1117/12.384160
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