Noninvasive in-vivo tissue-modulated near-infrared vibrational spectroscopic study of mobile and static tissues: blood chemistry

Joseph Chaiken; William F. Finney; Charles M. Peterson; Karen P. Peterson; Paul E. Knudson; Ruth S. Weinstock; Paul Lein

doi:10.1117/12.384957

8 May 2000 Noninvasive in-vivo tissue-modulated near-infrared vibrational spectroscopic study of mobile and static tissues: blood chemistry

Joseph Chaiken, William F. Finney, Charles M. Peterson, Karen P. Peterson, Paul E. Knudson, Ruth S. Weinstock, Paul Lein

Author Affiliations +

Proceedings Volume 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques; (2000) https://doi.org/10.1117/12.384957
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We report the first noninvasive Raman spectra of in vivo human blood. 'Tissue modulation' involves the use of thermal and/or mechanical stimulus to produce particular spatiotemporal distributions of mobile tissues, i.e. capillary blood, among nonmobile tissues, i.e. epidermis. Using this approach we have obtained three mutually independent lines of evidence, which unequivocally associate Raman spectra we have obtained with human blood. These spectral compare well with published spectra from other researchers of in vitro human blood. The results of a recent clinical study comparing our noninvasive in vivo spectroscopic measurements with simultaneous conventional in vitro measurements clearly demonstrate the efficacy of the tissue modulation approach. These results will be discussed in the context of noninvasive monitoring of a variety of analytes, i.e. glucose.

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Joseph Chaiken, William F. Finney, Charles M. Peterson, Karen P. Peterson, Paul E. Knudson, Ruth S. Weinstock, and Paul Lein "Noninvasive in-vivo tissue-modulated near-infrared vibrational spectroscopic study of mobile and static tissues: blood chemistry", Proc. SPIE 3918, Biomedical Spectroscopy: Vibrational Spectroscopy and Other Novel Techniques, (8 May 2000); https://doi.org/10.1117/12.384957

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