Creation of a virtual cutaneous tissue bank

William A. LaFramboise; Sujal Shah; R. W. Hoy; D. Letbetter; P. Petrosko; R. Vennare; Peter C. Johnson

doi:10.1117/12.384233

27 April 2000 Creation of a virtual cutaneous tissue bank

William A. LaFramboise, Sujal Shah, R. W. Hoy, D. Letbetter, P. Petrosko, R. Vennare, Peter C. Johnson

Proceedings Volume 3921, Optical Diagnostics of Living Cells III; (2000) https://doi.org/10.1117/12.384233
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Cellular and non-cellular constituents of skin contain fundamental morphometric features and structural patterns that correlate with tissue function. High resolution digital image acquisitions performed using an automated system and proprietary software to assemble adjacent images and create a contiguous, lossless, digital representation of individual microscope slide specimens. Serial extraction, evaluation and statistical analysis of cutaneous feature is performed utilizing an automated analysis system, to derive normal cutaneous parameters comprising essential structural skin components. Automated digital cutaneous analysis allows for fast extraction of microanatomic dat with accuracy approximating manual measurement. The process provides rapid assessment of feature both within individual specimens and across sample populations. The images, component data, and statistical analysis comprise a bioinformatics database to serve as an architectural blueprint for skin tissue engineering and as a diagnostic standard of comparison for pathologic specimens.

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William A. LaFramboise, Sujal Shah, R. W. Hoy, D. Letbetter, P. Petrosko, R. Vennare, and Peter C. Johnson "Creation of a virtual cutaneous tissue bank", Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); https://doi.org/10.1117/12.384233

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KEYWORDS

Tissues

Databases

Statistical analysis

Skin

Image resolution

Information science

Digital imaging

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