Progress toward implantable fluorescence-based sensors for monitoring glucose levels in interstitial fluid

Michael J. McShane; Dennis P. O'Neal; Ryan J. Russell; Michael V. Pishko; Gerard L. Cote

doi:10.1117/12.387127

31 May 2000 Progress toward implantable fluorescence-based sensors for monitoring glucose levels in interstitial fluid

Michael J. McShane, Dennis P. O'Neal, Ryan J. Russell, Michael V. Pishko, Gerard L. Cote

Proceedings Volume 3923, Optical Diagnostics of Biological Fluids V; (2000) https://doi.org/10.1117/12.387127
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

A painless monitoring procedure for diabetics has proven to be an elusive goal. While completely noninvasive measurements are the desired technique, minimally invasive procedures using implanted fluorescence sensor chemistry offer significant advantages in specificity over current noninvasive approaches. The goal was to evaluate the potential for transdermal glucose sensing using intensity measurements from implanted microspheres. A fiber-optic probe and spectrometer were custom-built for collection of in vivo data. Comparisons with commercial fluorometers show the constructed device is adequate for this project.

Citation Download Citation

Michael J. McShane, Dennis P. O'Neal, Ryan J. Russell, Michael V. Pishko, and Gerard L. Cote "Progress toward implantable fluorescence-based sensors for monitoring glucose levels in interstitial fluid", Proc. SPIE 3923, Optical Diagnostics of Biological Fluids V, (31 May 2000); https://doi.org/10.1117/12.387127

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