22 March 2000 Expression ratio statistics and its applications to microarray data analysis
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Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380505
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
Abstract
Microarray technology makes it possible to monitor expression levels of thousands of genes simultaneously during single or multiple experiments. Routinely, in order to analyze gene expressions level quantitatively, two fluorescent-labeled RNAs are hybridized to an array of cDNA probes on a glass slide. Ratios of gene expression levels arising from two co-hybridized samples are obtained through image segmentation and signal detection methods. During the past three years, we have developed a gene expression analysis system in which ratio statistics have been applied to expression analysis, and a ratio confidence interval has been established to identify ratio outliers.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yidong Chen, Vishnu G. Kamat, Edward R. Dougherty, Michael L. Bittner, Paul S. Meltzer, Jeffrey M. Trent, "Expression ratio statistics and its applications to microarray data analysis", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); doi: 10.1117/12.380505; https://doi.org/10.1117/12.380505
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