Pharmaceutical applications of photothermal cytometry

Dmitry Lapotko; Tat'yana Romanovskaya

doi:10.1117/12.380518

22 March 2000 Pharmaceutical applications of photothermal cytometry

Dmitry Lapotko, Tat'yana Romanovskaya

Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380518
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We describe two optical methods for in vitro drug trials on living cells and cell cultures. Response of each single target cell to drug impact is measured as the change of cell functional and structural state by photothermal imaging and the changes of cell viability is controlled with Laser Viability Test. Both photothermal methods are sensitive to specific cell reaction but although to reaction of general origin. High sensitivity of the methods allows to use minor amounts of drug and cell materials. Pharmaceutical applications are illustrated with the results of in vitro experiments being obtained for human living blood cells.

Citation Download Citation

Dmitry Lapotko and Tat'yana Romanovskaya "Pharmaceutical applications of photothermal cytometry", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); https://doi.org/10.1117/12.380518

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