22 March 2000 Pharmaceutical applications of photothermal cytometry
Author Affiliations +
Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380518
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States
We describe two optical methods for in vitro drug trials on living cells and cell cultures. Response of each single target cell to drug impact is measured as the change of cell functional and structural state by photothermal imaging and the changes of cell viability is controlled with Laser Viability Test. Both photothermal methods are sensitive to specific cell reaction but although to reaction of general origin. High sensitivity of the methods allows to use minor amounts of drug and cell materials. Pharmaceutical applications are illustrated with the results of in vitro experiments being obtained for human living blood cells.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dmitry Lapotko, Dmitry Lapotko, Tat'yana Romanovskaya, Tat'yana Romanovskaya, } "Pharmaceutical applications of photothermal cytometry", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); doi: 10.1117/12.380518; https://doi.org/10.1117/12.380518


Photothermal microscopy for cell imaging and diagnostics
Proceedings of SPIE (March 29 1995)
Photothermal imaging
Proceedings of SPIE (January 31 1995)
Photothermal technique in cell microscopy studies
Proceedings of SPIE (January 01 1995)
Laser viability method for red blood cells state monitoring
Proceedings of SPIE (January 14 1996)

Back to Top