Periodic mesoporous oxides are usually synthesized from water/surfactant system with low surfactant concentrations and 1,3,5-trimethylbenzene has been sued as a swelling agent to increase the spore size under certain conditions. The use of pre-formed liquid crystal phases as template in multicomponent system holds promise for even large pore sizes, large monoliths, and a high level of phase, pore size, and morphology control. Here a generalized method has ben employed to prepare liquid crystal phase that subsequently act as template for the formation of periodic mesoporous silica. Once formed, liquid crystal phases persist throughout the inorganic polymerization and gelation processes and directly template the formation of inorganic mesophases. The method is applicable to a diversity of chemical compositions and offers a simultaneous control over the pore size and morphology. Synthetic variables that can be used to tune the pore size include cosurfactant chain length, cosurfactant/surfactant mass ratios, and the amount of oil. The removal of organic components leads to periodic mesoporous silica with excellent thermal and hydrothermal stability.