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20 April 2000 Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI
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Contrast enhanced MRI (CE-MRI) is increasingly being used for tumor characterization as well as therapy response monitoring. We are investigating the diagnostic value of fast, multi-slice [1.5X1.5X5(mm)] CE-MRI with a time interval of 2(s) to enables estimating perfusion parameters. A clinical visualization tool is being developed that estimates curve parameters on a per voxel basis to be able to analyze the heterogeneous tumor physiology. MRI image noise strongly affects the (perfusion) related start-of-enhancement and time- to-peak estimates especially in low contrast curves. We therefore developed a robust estimation method. It was tested on realistic simulations and in vivo CE-MRI data and compared to existing methods. The new method is shown to be more accurate, precise and robust than common least-squares optimization based methods.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Henkjan J. Huisman and J. O. Barentsz "Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000);

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