20 April 2000 Contrast enhancement maps for lung lesions imaged on CT
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The purpose of this research was to use contrast enhanced spiral CT and image processing techniques to provide physiological information about the blood supply of lung lesions. This is useful for assessing solitary pulmonary nodules as well as evaluating treatment efficacy for lung cancer patients using tumor angiogenesis inhibition factors. A dynamic, contrast-enhanced spiral CT protocol was used to acquire a series of scans through the lesion both prior to contrast injection as well as at t equals 45, 90, 180 and 300 s post-injection. Lesion boundaries were then segmented for a single representative image at each time. After registration, the enhancement for each voxel was determined by subtracting the attenuation values of the pre-contrast reference voxels from the post-contrast values. Enhancement maps were then generated using these difference values. The mean and standard deviation enhancement values for each lesion were also measured. From preliminary analysis, the mean enhancement value was 100 plus or minus 24 HU for malignant lesions and 55 plus or minus 33 HU for benign lesions. Enhancement maps were generated and color-coded to demonstrate the variation of enhancement within lesions. This work presents preliminary results using contrast enhanced spiral CT imaging to detect differences between enhancing and non-enhancing lesions.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Michael F. McNitt-Gray, Michael F. McNitt-Gray, Matthew S. Brown, Matthew S. Brown, Nathaniel Wyckoff, Nathaniel Wyckoff, Jonathan G. Goldin, Jonathan G. Goldin, Robert Suh, Robert Suh, Denise R. Aberle, Denise R. Aberle, "Contrast enhancement maps for lung lesions imaged on CT", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); doi: 10.1117/12.383442; https://doi.org/10.1117/12.383442

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