20 April 2000 New method for volumetric estimation of functioning thyroid tissue
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99m-Tc-pertechnetate SPECT studies of thyroid phantoms, with volumes in 13-198 cc range, and of a number of patients were performed. A modified reconstruction and analytic methods were applied to the data analysis. It involved: (1) transformation of the initial ECT data by a suitable mathematical function to compress the dynamical range of the data; (2) tomographic reconstruction resulting in transaxial (TV) images; (3) decompression of TV images via a reverse function; (4) Gaussian smoothing of the decompressed TV (dTV) images; (5) subtraction of a Compton dTV images from photopeak dTV images, (6) parallel operation on dTV images: Sobel edge detection and impulse filtering; (7) combining the filtered images via the AND operator; (8) edge tracing in the combined image by a human operator; (9) volume estimation by a computer. Based on the phantom studies it was established that the proposed technique yielded volumes with the relative error not exceeding 10%. For patient studies, the obtained volumes were also compared with palpation estimation. It has been found that inter-observer variability of the thyroid volume estimate is a function of physician's experience in utilization of manual palpation and it may result in the relative errors exceeding 50%.
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David H. Feiglin, David H. Feiglin, Andrzej Krol, Andrzej Krol, George M. Gagne, George M. Gagne, Bradford J. Hellwig, Bradford J. Hellwig, Frank Deaver Thomas, Frank Deaver Thomas, } "New method for volumetric estimation of functioning thyroid tissue", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); doi: 10.1117/12.383434; https://doi.org/10.1117/12.383434


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