Reproducible measurements based on myocardial perfusion studies for patient follow-up

Jean-Philippe Thirion; Scott Leonard; Robert Hendel

doi:10.1117/12.383422

20 April 2000 Reproducible measurements based on myocardial perfusion studies for patient follow-up

Jean-Philippe Thirion, Scott Leonard, Robert Hendel

Proceedings Volume 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images; (2000) https://doi.org/10.1117/12.383422
Event: Medical Imaging 2000, 2000, San Diego, CA, United States

Abstract

Our aim is to derive quantitative measurements from Myocardium Perfusion Scintigraphic (MPS) exams for drug trials on Myocardium re-perfusion. We are considering 19 patients imaged 6 times to measure the effects of various conditions of SPECT acquisition (Sestamibi stress and Thallium rest). We are also measuring the stability of various indices of perfusion evolution. Our method is based on intra-patients image matching techniques for follow-up and on inter-patients matching with a reference model based on 100 normal subjects to define perfusion abnormalities. We are measuring intensity differences between normalized images of 10% for Sestamibi and 14% for Thallium. Correlation between image acquisitions is 95% for Sestamibi and 88% for Thallium. Our most stable index is the deficit load, being the integral over stress defects of perfusion deficit. For our 19 cases, deficit load average is 8% of global normal perfusion (GNP), standard deviation between 2 acquisitions is about 0.5% GNP with a -0.4% GNP systematic bias, and correlation between 2 acquisitions is 99.8%. The stability of the index is demonstrated and we expect that a deficit load variation of more than 2% GNP is significant of an evolution, which has to be confirmed by ongoing retrospective drug trials.

Citation Download Citation

Jean-Philippe Thirion, Scott Leonard, and Robert Hendel "Reproducible measurements based on myocardial perfusion studies for patient follow-up", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); https://doi.org/10.1117/12.383422

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available