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6 June 2000 Mutual information-based registration of cardiac ultrasound volumes
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Real-time volume ultrasound imaging of the heart is a new trend, and the registration of acquired volume framesets is clinically important. This registration may be accomplished by processing a selected pair of volume frames having identical cardiac phase (preferably end diastolic) from two framesets. The registration solves for the optimal rigid transformation between selected volumes through maximization of mutual information, a voxel similarity measure. The accuracy of registration was estimated through retrieval of an artificially introduced misalignment. Two volume frames, belonging to the same frameset and separated in time by 250 ms, were selected. The secondary volume was translated by seven voxels along each axis and rotated by seven degrees about each axis relative to the primary prior to registration. The translational mismatch upon registration was within one voxel and the rotational mismatch less than two degrees. Reduction of the speckle noise by spatio-temporal averaging followed by intensity binning was a key step in successful application of mutual information approach to ultrasound imaging. The application of our method to nine framesets arising from four different patients demonstrates the feasibility of using of mutual information for automatic registration of cardiac ultrasound data.
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Vladimir Zagrodsky, Raj Shekhar, and J. Fredrick Cornhill "Mutual information-based registration of cardiac ultrasound volumes", Proc. SPIE 3979, Medical Imaging 2000: Image Processing, (6 June 2000);

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