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6 June 2000 New approach to measure border irregularity for melanocytic lesions
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One of the important clinical features to differentiate benign melanocytic nevi from malignant melanomas is the irregularity of the lesion border. A careful examination of a lesion border reveals two types of irregularity: texture irregularity and structure irregularity. Texture irregularities are the small variations along the border, while structure irregularities are the global indentations and protrusions, which may suggest excess of cell growth or regression of a melanoma. Therefore, measuring border irregularity by structural indentations and protrusions may detect the malignancy of the lesion. The common shape descriptors such as compactness index and fractal dimension are more sensitive to texture irregularities than structure irregularities. They do not provide an accurate estimation for the structure irregularity. Therefore, we have designed a new measurement for border irregularity. The proposed method first locates all indentations and protrusions along the lesion border. Then a new area-based index, called irregularity index, is computed for each indentation and protrusion. The overall border irregularity is estimated by the sum of all individual indices. In addition, the new method offers an extra feature: localization of the significant indentations and protrusions. As the result, the new measure is sensitive to structure irregularities and may be useful for diagnosing melanomas.
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Tim Kam Lee and M. Stella Atkins "New approach to measure border irregularity for melanocytic lesions", Proc. SPIE 3979, Medical Imaging 2000: Image Processing, (6 June 2000);

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