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6 June 2000 Quantitative validation of a deformable cortical surface model
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Accurate reconstruction of the human cerebral cortex from magnetic resonance (MR) images is important for brain morphometric analysis, image-guided surgery, and functional mapping. Previously, we have implemented a cortical surface reconstruction method that employs fuzzy segmentation, isosurfaces and deformable surface models. The accuracy of the fuzzy segmentation has been well-studied using simulated brain images. However, global quantitative validation of the cortical surface model has not been feasible due to the lack of a true representation of the cortical surface. In this paper, we have alternately validated the deformable surface model used in one cortical surface reconstruction method by using a metasphere computational phantom. A metasphere is a mathematically defined three-dimensional (3-D) surface that has convolutions similar to the cortex. We simulated 500 image volumes using metaspheres with various numbers and degrees of convolutions. Different levels of Gaussian noise were also incorporated. Quantification of the differences between the reconstructed surfaces and the true metasphere surfaces provides a measure of the deformable model accuracy in relation to the properties of the modeled object and data quality.
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Daphne N. Yu, Chenyang Xu, Maryam E. Rettmann, Dzung L. Pham, and Jerry L. Prince "Quantitative validation of a deformable cortical surface model", Proc. SPIE 3979, Medical Imaging 2000: Image Processing, (6 June 2000);

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