The refractive index matching of components of a highly scattering tissue has a strong influence on its transmittance, reflectance, polarization and coherence what can be considered as a new approach for tissue spectroscopy, imaging, laser therapy and surgery. Experimental data for in vitro, ex vivo, and in vivo studies of various solutions, gels and oils action on optical properties of human tissues are presented. The dynamics of tissue optical properties depending on matter diffusion rate within tissue is studied. The possible application of refractive index matching effect for tissue spectroscopy, imaging and thermotherapy is discussed.
Valery V. Tuchin, Valery V. Tuchin,
"Controlling of tissue optical properties", Proc. SPIE 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine, (6 April 2000); doi: 10.1117/12.381515; https://doi.org/10.1117/12.381515