30 December 1999 Novel drug form of chlorin e6
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Proceedings Volume 4059, Laser Use in Oncology II; (1999) https://doi.org/10.1117/12.375256
Event: Selected Papers on Laser Use in Oncology II, 1999, none, Armenia
A novel stable water-soluble form of well known photosensitizer chlorin e6 named `Photodithazine' has been obtained from Spirulina Platensis cyanobacteria as a noncovalent complex with N-methyl-D-glucosamine, and its biological characteristics evaluate, which proved to be as follows: in vitro photocytotoxicity was 1 (mu) M (EC50) as determined by the extent of DNA synthesis inhibition in CaOv cells after irradiation with 650 - 900 nm light, and 5 (mu) M (EC65) as determined using MTT test on PC12 cells after irradiation with 670 nm laser light at the doses of 15 and 20 J/cm2, respectively, with Al-sulfophthalocyanine `Photosense' (Russia) and oligomerized hematoporphyrin-IX mixture `Photogen' (Russia) being used as permitted reference drugs.
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O. Yu. Abakumova, O. Yu. Abakumova, Rudolf Ph. Baum, Rudolf Ph. Baum, Natalia Yu. Ermakova, Natalia Yu. Ermakova, A. T. Gradyushko, A. T. Gradyushko, T. N. Guseva-Donskaya, T. N. Guseva-Donskaya, Artashes V. Karmenyan, Artashes V. Karmenyan, U. M. Koraboyev, U. M. Koraboyev, V. P. Laptev, V. P. Laptev, V. M. Mechkov, V. M. Mechkov, L. M. Mikhailova, L. M. Mikhailova, N. G. Panferova, N. G. Panferova, Aleksei G. Rebeko, Aleksei G. Rebeko, Andrei V. Reshetnickov, Andrei V. Reshetnickov, M. V. Ryabov, M. V. Ryabov, Eugeny Ph. Stranadko, Eugeny Ph. Stranadko, Tatyana A. Tsvetkova, Tatyana A. Tsvetkova, O. S. Zhukova, O. S. Zhukova, } "Novel drug form of chlorin e6", Proc. SPIE 4059, Laser Use in Oncology II, (30 December 1999); doi: 10.1117/12.375256; https://doi.org/10.1117/12.375256

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