Drillings in zirconia coated Ni-superalloys is done by melt extraction with pulsed laser radiation provided by a Nd:YAG slab laser with microsecond pulse duration. This laser system distinguishes itself by a high beam quality and offers the possibility to investigate drilling of holes with a diameter of 200 micrometer by percussion drilling and trepanning. The quality of drilled holes, e.g. the heat affected zone (HAZ), the recast layer and the conicality, are presented. During drilling different process gases are used. The results in drilling velocities, melt thickness and chemical composition of the melting zone are shown for oxygen, argon and nitrogen by SEM and EDX. A numerical simulation of the trepanning process will be presented. The different time scales of the contributing physical processes related, for example, to the small melt film layer during trepanning are described. A coating is distributed on the multilayer system to protect the blade from recast. Aim of the investigation is the production of holes in a multilayer system, consisting of CMSX-4, VPS-MCrAlY and EB-PVD-zirconia. With this used laser system inclined holes up to 60 degrees in this layer system can be drilled. No recast layer and no spalling of the zirconia-layer are observed.