4 July 2000 In-vivo noninvasive glucose monitoring with optical heterodyne polarimetry in a range of 50 mg/dl to 100 mg/dl
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Abstract
An amplitude sensitive optical heterodyne polarimeter was setup in order to monitor noninvasively the aqueous glucose concentration in rabbit's eye. A range of the blood glucose from 35 mg/dl to 135 mg/dl was measured in vivo by biological glucose assay (BGA), while the optional rotation of the aqueous glucose was measured by a polarimeter simultaneously. The experimental results showed the consistence between these two independent measurements. There was no time delay between the blood glucose and the aqueous glucose when the blood glucose was descending after the insulin was injected. It was in contract to a 10 minutes time delay when the blood glucose was ascending. The detection sensitivity of the polarimeter was 4 mg/dl in the measurement.
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Wei-Shing Wang, Chien-Yuan Han, Pei-Chin Tu, Chien Chou, "In-vivo noninvasive glucose monitoring with optical heterodyne polarimetry in a range of 50 mg/dl to 100 mg/dl", Proc. SPIE 4082, Optical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications, (4 July 2000); doi: 10.1117/12.390545; https://doi.org/10.1117/12.390545
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