We report a means of fabricating hydrophilic domains in a hydrophobic background by lithographically patterning an adhesive hydrophobic layer. Organic polymer microlenses have been fabricated on these substrates using a dip-coating technique. Various lens shapes (circular, elliptical, square) have been fabricated on a variety of substrates (SiO2, SiN, GaAs, InP, etc), ranging in size from 2 - 500 micrometers in diameter, and having fill factors of up to 90%. Plano-convex and double-convex lenses have been fabricated as fast as f/1.38 and f/1.2, respectively. The performance of arrays of these microlenses was quantitatively analyzed and optimized.