Detection of glutamate in the eye by Raman spectroscopy

Alvin Katz; Erik F. Kruger; Glenn Minko; C. H. Liu; Richard B. Rosen M.D.; Robert R. Alfano

doi:10.1117/12.401625

29 September 2000 Detection of glutamate in the eye by Raman spectroscopy

Alvin Katz, Erik F. Kruger, Glenn Minko, C. H. Liu, Richard B. Rosen M.D., Robert R. Alfano

Proceedings Volume 4098, Optical Devices and Diagnostics in Materials Science; (2000) https://doi.org/10.1117/12.401625
Event: International Symposium on Optical Science and Technology, 2000, San Diego, CA, United States

Abstract

In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.

Citation Download Citation

Alvin Katz, Erik F. Kruger, Glenn Minko, C. H. Liu, Richard B. Rosen M.D., and Robert R. Alfano "Detection of glutamate in the eye by Raman spectroscopy", Proc. SPIE 4098, Optical Devices and Diagnostics in Materials Science, (29 September 2000); https://doi.org/10.1117/12.401625

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