29 September 2000 Detection of glutamate in the eye by Raman spectroscopy
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In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.
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Alvin Katz, Alvin Katz, Erik F. Kruger, Erik F. Kruger, Glenn Minko, Glenn Minko, C. H. Liu, C. H. Liu, Richard B. Rosen, Richard B. Rosen, Robert R. Alfano, Robert R. Alfano, } "Detection of glutamate in the eye by Raman spectroscopy", Proc. SPIE 4098, Optical Devices and Diagnostics in Materials Science, (29 September 2000); doi: 10.1117/12.401625; https://doi.org/10.1117/12.401625

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