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2 November 2000 Development of a multispectral autoradiography using a coded aperture
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Autoradiography is a useful imaging technique to understand biological functions using tracers including radio isotopes (RI's). However, it is not easy to describe the distribution of different kinds of tracers simultaneously by conventional autoradiography using X-ray film or Imaging plate. Each tracer describes each corresponding biological function. Therefore, if we can simultaneously estimate distribution of different kinds of tracer materials, the multispectral autoradiography must be a quite powerful tool to better understand physiological mechanisms of organs. So we are developing a system using a solid state detector (SSD) with high energy- resolution. Here, we introduce an imaging technique with a coded aperture to get spatial and spectral information more efficiently. In this paper, the imaging principle is described, and its validity and fundamental property are discussed by both simulation and phantom experiments with RI's such as 201Tl, 99mTc, 67Ga, and 123I.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Daisuke Noto, Tohoru Takeda, Jin Wu, Thet Thet Lwin, Quanwen Yu, Tsutomu Zeniya, Tetsuya Yuasa, Yukio Hiranaka, Yuji Itai, and Takao Akatsuka "Development of a multispectral autoradiography using a coded aperture", Proc. SPIE 4113, Algorithms and Systems for Optical Information Processing IV, (2 November 2000);


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