Promising cancer treatment modality: the University of California Davis/McClellan Nuclear Radiation Center neutron capture therapy program

Susan A. Autry-Conwell; James E. Boggan; Benjamin F. Edwards; Yongjin Hou; Maria-Graca Vincente; Hungyuan Liu; Wade J. Richards

doi:10.1117/12.410584

18 December 2000 Promising cancer treatment modality: the University of California Davis/McClellan Nuclear Radiation Center neutron capture therapy program

Susan A. Autry-Conwell, James E. Boggan, Benjamin F. Edwards, Yongjin Hou, Maria-Graca Vincente, Hungyuan Liu, Wade J. Richards

Author Affiliations +

Proceedings Volume 4142, Penetrating Radiation Systems and Applications II; (2000) https://doi.org/10.1117/12.410584
Event: International Symposium on Optical Science and Technology, 2000, San Diego, CA, United States

Abstract

Neutron capture therapy (NCT) is a promising new binary therapeutic modality for the treatment of localized tumors. It is accomplished by injection and localization within the tumor of a neutron capture agent (NCA) that alone, is non- toxic. Whenthe tumor is then exposed to neutrons, a relatively non-toxic form of radiation, crytotoxic products are produced that directly or indirectly cause tumor cell death, and yet preserves normal surrounding tissue not contain the NCA. The UC Davis NCT program is currently working to develop and test new compounds or NCA in vitro and in vivo. Many groups worldwide are also working to develop the next generation NCA, but less than five facilities internationally are currently capable to treating clinical brain tumor patients by NCT and only two US facilities, MIT and Brookhaven National Laboratory. In addition to compound development, the UC Davis NCT program is preparing the UC Davis McClellan Nuclear Radiation Center's 2 megawatt TRIGA reactor for NCT clinical trials which would make it the only such facility on the West Coast.

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Susan A. Autry-Conwell, James E. Boggan, Benjamin F. Edwards, Yongjin Hou, Maria-Graca Vincente, Hungyuan Liu, and Wade J. Richards "Promising cancer treatment modality: the University of California Davis/McClellan Nuclear Radiation Center neutron capture therapy program", Proc. SPIE 4142, Penetrating Radiation Systems and Applications II, (18 December 2000); https://doi.org/10.1117/12.410584

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KEYWORDS

Tumors

Brain

Gadolinium

Nuclear radiation

Particles

Tissues

Cancer

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