Endovascular photodynamic therapy inhibits intimal hyperplasia PTA in a rat model

Edward E. Gabeler M.D.; Richard van Hillegersberg; R. G. Statius van Eps; Wim Sluiter; D. Hayes M.D.; Hero van Urk

doi:10.1117/12.413698

31 January 2001 Endovascular photodynamic therapy inhibits intimal hyperplasia PTA in a rat model

Edward E. Gabeler M.D., Richard van Hillegersberg, R. G. Statius van Eps, Wim Sluiter, D. Hayes M.D., Hero van Urk

Proceedings Volume 4156, Clinical Lasers and Diagnostics; (2001) https://doi.org/10.1117/12.413698
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

Background: Vascular restenosis due to intimal hyperplasia (IH) and negative vascular remodeling attenuates long-term patency of vascular interventions like PT(C)As. A new adjuvant approach to PT(C)A is endovascular PDT, which is based on local cytotoxicity by intracellular activation of aminolevulinic acid included protoporfyrin IX with laser. Aim: To prevent restenosis by inhibiting IH with endovascular photodynamic therapy. Methods: Male Wistar rats were subdivided into four groups, the sham group, the IH reference-group with PTA induced denudation of the right iliac artery, and both the PTA+light only group and PTA +PDT group illuminated at 0,12.5, 25 and 50 Joule per cm diffuser length applied at 100 mW per cm diffuser length. Results: IH increased from 0 02 at 1 week to 0.13 mm² at 4 weeks. After 4 weeks, IH was 0.14mm² in the PTA +LO group compared to 0.002 mm² in the PTA+PDT group at 50 Joule per cm diffuser length, whereas the media remained. Conclusion: A single endovascular PDT treatment adjuvant to PTA inhibits IH after 4 weeks at an optimal light dosimetry of 50 Joules per cm diffuser length and 3 hours after ALA application in this IH model. Therefore, endovascular PDT is a promising therapy to prevent restenosis after vascular interventions.

Citation Download Citation

Edward E. Gabeler M.D., Richard van Hillegersberg, R. G. Statius van Eps, Wim Sluiter, D. Hayes M.D., and Hero van Urk "Endovascular photodynamic therapy inhibits intimal hyperplasia PTA in a rat model", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); https://doi.org/10.1117/12.413698

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