31 January 2001 Mortality in experimental adjuvant intraoperative photodynamic therapy (AIOPDT) using ALA, Photofrin II, and mTHPC
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Abstract
A clinical problem in the treatment of colorectal cancer is the high rate of local tumor recurrence. Adjuvant therapy methods are necessary to receive a better clinical outcome in minimizing local tumor relapse. Adjuvant intraoperative photodynamic therapy (AIOPDT) seems to be a promising alternative therapy in the treatment of malignant colorectal diseases. IN experimental settings the success of AIOPDT depends on the accumulation of the photosensitizer (PS) in tumor tissue and may be jeopardized by high mortality rates, due to inadequate energy doses. Our study evaluated mortality rates of nude mice after AIOPDT with ALA, Photofrin II and mTHPC using the following various light doses: ALA/Photofrin II: 100J, 50J, 25J; mTHPC: 30J, 15J, 5J generated by an Argon-Dye-laser system. There was a close correlation between laser energy applied for AIOPDT and postoperative mortality rate. Initial high mortality rates were lowered by stepwise reduction of the energy dose. Mortality rates reached a maximum 24 hours after AIOPDT in all groups.
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Steffi Winkler, Ruediger L. Prosst, Josef Stern, Markus Rheinwald, Thomas Haase, Christian Herfarth, Johannes Gahlen, "Mortality in experimental adjuvant intraoperative photodynamic therapy (AIOPDT) using ALA, Photofrin II, and mTHPC", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); doi: 10.1117/12.413714; https://doi.org/10.1117/12.413714
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