Mortality in experimental adjuvant intraoperative photodynamic therapy (AIOPDT) using ALA, Photofrin II, and mTHPC

Steffi Winkler; Ruediger L. Prosst; Josef Stern; Markus Rheinwald; Thomas Haase; Christian Herfarth; Johannes Gahlen

doi:10.1117/12.413714

31 January 2001 Mortality in experimental adjuvant intraoperative photodynamic therapy (AIOPDT) using ALA, Photofrin II, and mTHPC

Steffi Winkler, Ruediger L. Prosst, Josef Stern, Markus Rheinwald, Thomas Haase, Christian Herfarth, Johannes Gahlen

Author Affiliations +

Proceedings Volume 4156, Clinical Lasers and Diagnostics; (2001) https://doi.org/10.1117/12.413714
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

A clinical problem in the treatment of colorectal cancer is the high rate of local tumor recurrence. Adjuvant therapy methods are necessary to receive a better clinical outcome in minimizing local tumor relapse. Adjuvant intraoperative photodynamic therapy (AIOPDT) seems to be a promising alternative therapy in the treatment of malignant colorectal diseases. IN experimental settings the success of AIOPDT depends on the accumulation of the photosensitizer (PS) in tumor tissue and may be jeopardized by high mortality rates, due to inadequate energy doses. Our study evaluated mortality rates of nude mice after AIOPDT with ALA, Photofrin II and mTHPC using the following various light doses: ALA/Photofrin II: 100J, 50J, 25J; mTHPC: 30J, 15J, 5J generated by an Argon-Dye-laser system. There was a close correlation between laser energy applied for AIOPDT and postoperative mortality rate. Initial high mortality rates were lowered by stepwise reduction of the energy dose. Mortality rates reached a maximum 24 hours after AIOPDT in all groups.

Citation Download Citation

Steffi Winkler, Ruediger L. Prosst, Josef Stern, Markus Rheinwald, Thomas Haase, Christian Herfarth, and Johannes Gahlen "Mortality in experimental adjuvant intraoperative photodynamic therapy (AIOPDT) using ALA, Photofrin II, and mTHPC", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); https://doi.org/10.1117/12.413714

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

;

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE