31 January 2001 Photodynamic therapy in a cervico-uterine cancer cell line (HeLa) implanted in nu/nu mice
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Abstract
Pp IX accumulation induced by ALA was tested in a cell line of cervix carcinoma implanted in nu/nu mice, and irradiated by argon laser. It was found that the mice developed the tumor 17 days form its exposition to HeLa cells. The optimal concentration of ALA that induced maximum level of accumulation of PpIX in the tumors was 150 mg/kg by IT route. In ALA doses it was observed a decrease in the tumoral area in the first three radiations at 234.36 J/cm2. It was found that nu/nu Swiss mice with implanted HeLa cells are a good model to study the epidermoide carcinoma because tumor development time is short although is valid only during first 3 months. The histology study shows that there is no cellular damage immediates at the concentrations used. IT route does not allow a high PpIX accumulation in different organs, therefore this route is more safety. It was observed a decreasing size in the irradiated tumor by using an argon laser, this preliminaries results are indicating that would be possible to propose the use of this laser in PDT applied in EC.
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Eva Ramon Gallegos, Eva Ramon Gallegos, Salomon Hernandez Guitierrez, Salomon Hernandez Guitierrez, Leticia Garduno Siciliano, Leticia Garduno Siciliano, Jose Luis Jiminez Perez, Jose Luis Jiminez Perez, Aura Judith Perez Zapata, Aura Judith Perez Zapata, Alfredo Cruz Orea, Alfredo Cruz Orea, } "Photodynamic therapy in a cervico-uterine cancer cell line (HeLa) implanted in nu/nu mice", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); doi: 10.1117/12.413721; https://doi.org/10.1117/12.413721
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