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22 November 2000 Estimation of the optical sampling volume for skin reflectance measurements
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The absolute quantified measurement of haemoglobin skin blood saturation from collected reflectance spectra of the skin is complicated by the fact that the blood content of tissues can vary both in the spatial distribution and in the amount. These measurements require an understanding of which vascular bed is primarily responsible for the detected signal. Knowing the spatial detector depth sensitivity makes it possible to find the best range of different probe geometries for the measurements of signal from the required zones and group of vessels inside the skin. To facilitate this we have developed a Monte Carlo simulation to estimate the sampling volume offered by small source detector spacing (in the current report 250 micrometer, 400 micrometer and 800 micrometer) in the fiber-optic probes, and confocal microscope probe (the lens parameters are: diameter - 5 mm; focal length - 10 mm; the pinhole diameter is 10 micrometer). The optical properties of the modeled medium were taken to be the optical properties of the Caucasian type of skin tissues in visible range of the spectrum.
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Igor Victorovich Meglinski and Stephen John Matcher "Estimation of the optical sampling volume for skin reflectance measurements", Proc. SPIE 4160, Photon Migration, Diffuse Spectroscopy, and Optical Coherence Tomography: Imaging and Functional Assessment, (22 November 2000);

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