28 June 2000 Basic principles of fluorescence detection with use of 5-ALA
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5-Aminolevulinic acid (5-ALA) has been proven to induce selective accumulation of flourescent Protoporphyrin IX (PPIX) in many types of malignant tissue. According to the target to treatment different routes of topical and systemical application of 5-ALA can be chosen. They include techniques like inhalation, installation and rinsing. For fluorescence detection a lamp based system have been developed in the laser-Forschungslabor in Munich together with Storz company. By skillful balancing of excitation filter centered around 400 nm and the observation filter with transmission above 450 nm images with high color contrast can be obtained. The universal application of the D-LIGHT could be demonstrated in different clinical disciplines like urology, neurosurgery, ENT clinic, gynecology and others.
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Reinhold Baumgartner, Reinhold Baumgartner, Herbert G. Stepp, Herbert G. Stepp, "Basic principles of fluorescence detection with use of 5-ALA", Proc. SPIE 4166, Laser Florence '99: A Window on the Laser Medicine World, (28 June 2000); doi: 10.1117/12.389470; https://doi.org/10.1117/12.389470

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